Cisplatin Combined with Oral TS-1 in Patients with Advanced Solid Tumors with Different Degrees of Liver Dysfunction

The purpose of this study is to formally characterize the pharmacokinetics (PK), safety, and tolerability of TS-1 in combination with cisplatin in adult patients with advanced solid tumors who have mild, moderate or severe hepatic impairment relative to patients with normal hepatic function, as categorized by the United States National Cancer Institute organ dysfunction working group \[NCI-ODWG\] criteria for hepatic dysfunction.

NCT Number	NCT03519074
Lead Sponsor	National University Hospital, Singapore
Conditions	Cancer, Liver Dysfunction
Enrollment	48 participants
Start Date	2016-07-22
Primary Completion	2024-09-01 (estimated)
Study Completion	2025-12-20 (estimated)
Updated on ClinicalTrials.gov	2024-09-19