Post Acute Cardiac Event Smoking (PACES) Study

Summary of the Project : Quitting smoking following acute coronary syndrome (ACS) can reduce mortality up to 50%. However, depression and smoking are highly co-morbid and depressed mood may interfere with cessation and independently predicts mortality. Thus, a single, integrated treatment for both smoking and depression could be highly effective in reducing post-acute coronary syndrome mortality. Behavioral Activation (BA) is a well established treatment for depression and has recently shown promise as a treatment for smoking cessation. The investigators systematically developed an intervention integrating gold standard smoking cessation counseling with existing BA based mood management techniques for post-ACS smokers; Behavioral Activation Treatment for Cardiac Smokers (BAT-CS). Objective: For this R01 the investigators will evaluate the efficacy of using a single, integrated treatment that targets both depressed mood and smoking (BAT-CS).

NCT Number	NCT03413423
Lead Sponsor	Hennepin Healthcare Research Institute Collaborators: Minneapolis Heart Institute Foundation, The Miriam Hospital, National Heart, Lung, and Blood Institute (NHLBI), University of Minnesota
Conditions	Acute Coronary Syndrome, Tobacco Use
Enrollment	233 participants
Start Date	2018-01-29
Primary Completion	2024-05-08 (estimated)
Study Completion	2026-05-30 (estimated)
Updated on ClinicalTrials.gov	2025-09-15