Clinical Trial

ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant Depression

Recruiting Phase 4
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Record status
This record was last updated January 23, 2025 (before its estimated December 31, 2025 completion). Its status may not reflect the trial's current state.
Summary
To determine if an high intensity ketamine with ECT rescue (HIKER) approach for treatment resistant depression will: 1) reduce patient suffering by hastening disease remission, 2) have fewer side effects, 3) reduce the need for ECT, and 4) be preferred by most patients. Half of participants will be randomized to the HIKER arm and receive high intensity ketamine treatment for eight consecutive days, and the other half will be assigned to the ECT with ketamine anesthesia (EAST) arm and receive 8 ECT treatments (2-3 treatment/week)
Protocol Amendment History 8 amendments
This ClinicalTrials.gov record has been amended 8 times since 2017-09-01; most recent amendment 2025-01-20.
Status change: Not Yet Recruiting → Recruiting 2017-10-12
Trial Details
NCT Number NCT03272698
Lead Sponsor University of Saskatchewan
Collaborators: Royal University Hospital Foundation
Conditions Treatment Resistant Depression, Ketamine
Enrollment 62 participants
Start Date 2017-09-01
Primary Completion 2025-12-31 (estimated)
Study Completion 2025-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-01-23