Clinical Trial

Dynamics of Platelet Activation in Patients With Ventricular Assist Device (VAD)

Study acronym: PASVAD
Recruiting
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Summary
Consenting patients with end-stage heart failure that are implanted with/candidates for implant of a short-term/durable mechanical circulatory support device (e.g.: percutaneous microaxial pumps (Impella), extracorporeal membrane oxygenator (ECMO), Ventricular Assist Device (VAD) will be enrolled in the study. Aim of the study is to evaluate the patients' haemostatic and coagulation profile, how it interacts with the support device as well as the effect of antithrombotic drugs. From these data, it will be possible to derive the mechanisms triggering post-implant thromboembolic/hemorrhagic complications and to identify potential therapeutic targets.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2017-08-16; most recent amendment 2025-05-12.
Trial Details
NCT Number NCT03255928
Lead Sponsor Scientific Institute San Raffaele
Collaborators: Università Vita-Salute San Raffaele
Conditions Thrombosis, Blood Coagulation Disorder, Platelet Thrombus, Platelet Dysfunction Due to Aspirin, Failure;Ventricular
Enrollment 60 participants
Start Date 2017-06-29
Primary Completion 2026-12-31 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-05-15