Potassium Supplementation in CKD

The current high-sodium, low-potassium diet contributes to the high prevalence of high blood pressure (hypertension). Indeed, the anti-hypertensive effects of potassium supplementation are well-established. Hypertension is even more prevalent and resistant in patients with chronic kidney disease (CKD) and contributes to further decline in kidney function. Four recent epidemiological studies (published 2014 - 2016) showed that higher dietary potassium intake was associated with better renal outcomes. All studies recommended an intervention study with potassium supplementation in patients with CKD, but this has not been performed. The aim of this study is to study the renoprotective effect of potassium supplementation in patients with CKD (stage 3b or 4, i.e. estimated glomerular filtration rate \[eGFR\] 15 - 45 ml/min/1.73 m2).

NCT Number	NCT03253172
Lead Sponsor	Erasmus Medical Center Collaborators: Dutch Kidney Foundation, University Medical Center Groningen, Leiden University Medical Center, Amsterdam UMC
Conditions	Renal Insufficiency, Chronic, Potassium Depletion, Hypertension, Hyperkalemia
Enrollment	532 participants
Start Date	2017-07-01
Primary Completion	2026-09-01 (estimated)
Study Completion	2026-10-01 (estimated)
Updated on ClinicalTrials.gov	2026-08-10