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NCT03148106 · ClinicalTrials.gov record · last posted 2026-08-20

Hand Rehabilitation Study for Stroke Patients

Study acronym: DOSES
StatusTerminated
PhaseNot applicable
Started2017-04-04
View on ClinicalTrials.gov ↗
Why the trial stopped
COVID19 Pandemic
from the ClinicalTrials.gov record
The purpose of this study is to find out what are the best settings for applying electrical nerve stimulation over the skin for the short-term improvement of hand dysfunction after a stroke. The ultimate goal is to some day design an effective long-term training program to help someone recovery their ability to use their hands and function independently at home and in society. In order to know how to apply electrical nerve stimulation to produce a good long-term effect on hand dysfunction, the investigators first need to know how to make it work best in the short-term, and improve our understanding of for whom it works and how it works. The investigators will use a commercially available transcutaneous electrical nerve stimulation (TENS) unit to gently apply electrical nerve stimulation over the skin of the affected arm. This is a portable, safe and easy to use device designed for patients to operate in their homes.

Protocol amendment history 5 changes detected by DataLookout

2026-08-21
critical
Trial terminated
2026-08-21
critical
Trial terminated: COVID19 Pandemic
2026-08-21
critical
Enrollment reduced: 25 → 14 participants
2026-08-21
minor
Primary completion moved earlier: 2028-12-01 → 2025-12-02
2026-08-21
minor
Completion moved earlier: 2028-12-01 → 2025-12-02
Trial Details
NCT Number NCT03148106
Lead Sponsor University of California, San Francisco
Collaborators: National Institute of Mental Health (NIMH)
Conditions Upper Extremity Paresis, Disability Physical, Chronic Stroke, Motor Disorders
Enrollment 14 participants
Start Date 2017-04-04
Primary Completion 2025-12-02 (estimated)
Study Completion 2025-12-02 (estimated)
Updated on ClinicalTrials.gov 2026-08-20