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Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic

StatusActive, Not Recruiting
PhasePhase 1
Started
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Record History

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  1. Primary and study completion dates: Feb 2026 to Dec 2026v18
  2. Primary and study completion dates: Nov 2025 to Feb 2026v17
  3. Primary completion date: Aug 2025 to Nov 2025v16
  4. Primary completion date: Aug 2024 to Aug 2025
    • Study completion date: Nov 2024 to Nov 2025
    v15
  5. Primary completion date: Aug 2023 to Aug 2024
    • Study completion date: Nov 2023 to Nov 2024
    v14
Show 12 earlier versionsHide 12 earlier versions
  1. Re-verified, no change to tracked fieldsv13
  2. Primary completion date: Aug 2022 to Aug 2023
    • Study completion date: Nov 2022 to Nov 2023
    v12
  3. Primary completion date: Aug 2021 to Aug 2022
    • Study completion date: Nov 2021 to Nov 2022
    v11
  4. Primary completion date: Mar 2021 to Aug 2021
    • Study completion date: Mar 2021 to Nov 2021
    v10
  5. Re-verified, no change to tracked fieldsv9
  6. Enrollment target: estimated 32 to confirmed 2
    • Trial status: Recruiting to Active, Not Recruiting
    • Site details revised
    v8
  7. Site contact updatedv7
  8. Re-verified, no change to tracked fieldsv6
  9. Phase: Not applicable to Phase 1v5
  10. 2 versions Re-verified since Aug 2, 2016, no change to tracked fieldsv3-v4
  11. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 0 to 1
    • Start date: Mar 2016 to Apr 2016
    • Study description expanded, about 1 word
    v2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The purpose of this study is to learn more about the regulation of the veins of the abdomen by the autonomic (involuntary) nervous system, and how this may affect high blood pressure. Normally, the autonomic nervous system controls how much blood flows in the veins. In people with high blood pressure, however, the autonomic nervous system is changed. This change may affect the way blood flows in the veins of the abdomen which may play a role in their high blood pressure. About 32 participants will be screened for the study. The investigators estimate 16 will be eligible to participate in all of the study days.
Trial Details
NCT Number NCT02726711
Lead Sponsor Vanderbilt University
Conditions
(from sponsor)		 Multiple System Atrophy, Orthostatic Hypotension, Supine Hypertension
Related terms Hypotension, Orthostatic, Multiple System Atrophy
Enrollment 2 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov