Clinical Trial

Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic

Active, Not Recruiting Phase 1
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Summary
The purpose of this study is to learn more about the regulation of the veins of the abdomen by the autonomic (involuntary) nervous system, and how this may affect high blood pressure. Normally, the autonomic nervous system controls how much blood flows in the veins. In people with high blood pressure, however, the autonomic nervous system is changed. This change may affect the way blood flows in the veins of the abdomen which may play a role in their high blood pressure. About 32 participants will be screened for the study. The investigators estimate 16 will be eligible to participate in all of the study days.
Protocol Amendment History 17 amendments
This ClinicalTrials.gov record has been amended 17 times since 2016-03-29; most recent amendment 2026-03-11.
Status change: Recruiting → Active, Not Recruiting 2020-02-08
Status change: Not Yet Recruiting → Recruiting 2016-04-26
Trial Details
NCT Number NCT02726711
Lead Sponsor Vanderbilt University
Conditions Multiple System Atrophy, Orthostatic Hypotension, Supine Hypertension
Enrollment 2 participants
Start Date 2016-04
Primary Completion 2026-12 (estimated)
Study Completion 2026-12 (estimated)
Updated on ClinicalTrials.gov 2026-03-13