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Response of the Myocardium to Hypertrophic Conditions in the Adult Population

StatusRecruiting
PhaseNot specified
Started
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Record History

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  1. Study description expanded, about 44 wordsv5
  2. Enrollment target: 1000 to 2000
    • Primary and study completion dates: Sep 2021 to Sep 2031
    • Study title expanded, about 7 words
    v4
  3. Enrollment target: 500 to 1000v3 Show 5 more changesShow less
    • Primary completion date: Jan 2018 to Sep 2021
    • Study completion date: May 2018 to Sep 2021
    • Interventions: Ambulatory Blood Pressure Monitoring (Device), Cardiovascular Magnetic Resonance (Other), Echocardiogram (Other), Electrocardiogram (Other) to Ambulatory Blood Pressure Monitoring (Device), Cardiovascular Magnetic Resonance (Other), Echocardiogram (Other), Electrocardiogram…
    • Site details revised
    • Publications: 15 to 2
  4. Re-verified, no change to tracked fieldsv2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Hypertension and aortic stenosis are the two leading conditions that cause thickening of the heart muscles (left ventricular hypertrophy). Left ventricular hypertrophy is initially adaptive to maintain optimal heart function. Ultimately, heart failure occurs as a result of progressive muscle cell death and scarring (myocardial fibrosis). Dedicated techniques using cardiovascular magnetic resonance imaging (MRI) and novel high-sensitivity cardiac troponin blood assays are potential markers to detect myocardial fibrosis. Although hypertension-related heart disease is very common in Singapore, the significance of myocardial fibrosis is not well understood. In this study, the significance of myocardial fibrosis in 2000 patients with hypertension would be investigated. This will be the largest study using state-of-the-art MRI to examine the importance of myocardial fibrosis in hypertensive heart disease. 1000 participants, with at least 1 year follow-up, will be invited for a repeat assessment.
Trial Details
NCT Number NCT02670031
Lead Sponsor National Heart Centre Singapore
Conditions
(from sponsor)		 Left Ventricular Hypertrophy, Hypertension, Myocardial Fibrosis
Related terms Hypertension, Hypertrophy, Left Ventricular
Enrollment 2,000 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov