Acupuncture or Metformin for Insulin Resistance in Women With PCOS

The hypothesis is that acupuncture is equally effective as metformin (both treatments combined with lifestyle management) in improving whole body glucose homeostasis in insulin resistant women with polycystic ovary syndrome (PCOS), and that both are superior to lifestyle management alone. The investigators hypothesize that acupuncture and metformin induce ovulation and improve hyperandrogenism, as well as health related quality of life (HRQoL) and symptoms of anxiety and depression. Although equally effective (acupuncture and metformin), the investigators hypothesize that acupuncture is associated with less negative side-effects. The investigators also hypothesize that these treatments have the potential to restore epigenetic and molecular alterations in target tissues (endometrial-, adipose-, and skeletal muscle tissue) and thus have the potential to prevent the development of type 2 diabetes (T2D).

NCT Number	NCT02647827
Lead Sponsor	Karolinska Institutet Collaborators: Karolinska University Hospital, Peking University
Conditions	Polycystic Ovary Syndrome, Insulin Resistance, Hyperandrogenism
Enrollment	303 participants
Start Date	2015-12
Primary Completion	2025-06 (estimated)
Study Completion	2026-06 (estimated)
Updated on ClinicalTrials.gov	2024-10-09