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AMH as a Predictor of Infertility Risk in Children With Cancer (CHANCE)

Study acronym: CHANCE
StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 5 years later Dec 2021 → Dec 31, 2026
See other at-risk trials from Erasme University Hospital

Record History

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  1. Primary completion pushed from Dec 2021 to Dec 31, 2026
    • Study completion pushed from Dec 2036 to Dec 31, 2041
    • Study sites: 10 to 8
    v6
  2. Primary completion date: Dec 2020 to Dec 2021
    • Study completion date: Dec 2035 to Dec 2036
    • Eligibility criteria expanded, about 8 words
    • Study description expanded, about 9 words
    v5
  3. Primary completion date: Apr 2017 to Dec 2020
    • Study completion date: Apr 2031 to Dec 2035
    • Study sites revised (10)
    v4
  4. Site details revised at 2 of 10 sitesv3
  5. Secondary endpoints: details revised at 1 of 2 entriesv2
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
While most of the children spontaneously recover menstruation or experienced normal puberty after chemotherapy, their ovarian reserve may be impaired by treatment inducing future infertility. Fertility preservation is currently proposed for selected prepubertal patients with a high risk of premature ovarian failure after treatment (mostly conditioning regimen for bone marrow transplantation). For patients with low or moderate risks, counselling is very difficult and no fertility preservation procedure is usually proposed for these patients as no marker of the ovarian reserve has been validated in this young population to assess the individual risk. The primary objective of the study is to prevent long-term treatment-related infertility by detecting the young patients who normally progressed to menarche but have a reduced ovarian reserve. These patients may benefit from particular follow-up and fertility preservation procedure.
Trial Details
NCT Number NCT02595255
Lead Sponsor Erasme University Hospital
Collaborators: Queen Fabiola Children's University Hospital
Conditions
(from sponsor)		 Fertility Preservation, Lymphoma, Pediatrics Cancer, Gonadotropin-releasing Hormone Agonist
Related terms Lymphoma
Enrollment 275 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov