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Cont. of a Study to Evaluate Implanting Peripheral Nerve Grafts Into Subjects With Parkinson's Disease (PD) During DBS

Study acronym: CAPNG
StatusActive, Not Recruiting
PhasePhase 1
Started2015-02
View on ClinicalTrials.gov ↗
This pilot study is designed to follow up on a previous, preliminary study and test the long-term safety and feasibility of the implantation of autologous peripheral nerve grafts into the substantia nigra, basal forebrain, putamen, and/or STN of participants with PD undergoing deep brain stimulation (DBS) surgery. Peripheral nerve tissue contains Schwann cells which produce growth factors that have been demonstrated to support the survival and function of neurons. Participants will serve as their own donor for the tissue, which will be implanted at the time they undergo DBS surgery.

Amendment record

Amended 10 times since 2015-02-16; most recent filed 2025-10-24. Every amendment is listed below.

Dates here are the day the sponsor filed the amendment, not the day ClinicalTrials.gov published it. Version history last read from ClinicalTrials.gov on 2026-08-31.

2025-10-24
Amendment Study Status, Oversight, References v10
2025-04-03
Amendment Study Identification, Study Status, References v9
2024-11-07
Amendment Study Identification, Study Status, Oversight, References v8
2023-11-10
Amendment Study Status, References v7
2022-11-10
Amendment Study Identification, Study Status, Outcome Measures, References v6
2022-05-04
Amendment Enrolling by Invitation→Active, Not Recruiting Study Status, Study Design v5
2021-05-12
Amendment Study Status, References v4
2020-01-18
Amendment Study Status, Outcome Measures v3
2018-08-31
Amendment Study Status, Study Description, Study Design, Arms and Interventions, Eligibility, References v2
2016-03-08
Amendment Not Yet Recruiting→Enrolling by Invitation Study Identification, Study Status, Study Description, Study Design, Arms and Interventions, Outcome Measures, Contacts/Locations, References v1
2015-02-16
Original filing
Trial Details
NCT Number NCT02369003
Lead Sponsor Craig van Horne, MD, PhD
Conditions Parkinson's Disease
Enrollment 70 participants
Start Date 2015-02
Primary Completion 2027-09 (estimated)
Study Completion 2027-09 (estimated)
Updated on ClinicalTrials.gov 2026-08-31