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Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Record History

The 50 most recent of 329 record versions are accounted for below. See every version on ClinicalTrials.gov ↗

  1. Re-verified, no change to tracked fields
  2. Re-verified, no change to tracked fields
  3. Eligibility criteria expanded, about 16 words
  4. 5 versions Re-verified since Aug 5, 2026, no change to tracked fieldsv322-v326
  5. Eligibility criteria shortened, about 7 wordsv321 See this version in full on ClinicalTrials.gov ↗
Show 41 earlier versionsHide 41 earlier versions
  1. 27 versions Re-verified since Sep 16, 2025, no change to tracked fieldsv294-v320
  2. Study Status, Eligibilityv293
  3. 13 versions Re-verified since Mar 14, 2025, no change to tracked fieldsv280-v292
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Background: \- Biomarkers are substances in people's blood and tissues. They help researchers understand diseases and signs of aging. Scientists want to do more research on biomarkers to find ways to improve quality of life in old age. Objective: \- To learn more about biomarkers and their relationship to aging. Eligibility: \- Adults at least 20 years old who weigh at least 110 pounds and have a body mass index below 30. They must agree that their genetic samples can be collected, studied, and stored. Design: * Participants will be screened with medical history, physical exam, EKG and blood and urine tests. * Participants will have 3-day visits. They will return every 2 years. * All visits include: * Blood and urine collection * Physical performance tests * Health questionnaires * Memory and problem-solving tests * Magnetic Resonance Imaging (MRI) and Computerized Tomography (CT) scans. * Muscle metabolism/ exercise tests * Taste strips * Muscle and/or skin biopsies/ red light therapy * Retinal imaging/ eye tracking * Sleep study * ODD visits also include: * Cytapheresis * Bone marrow aspirate * EVEN visits also include: * Hyperglycemic CLAMP * Lumbar Puncture (LP) * Continuous Glucose Monitor (CGM)
Trial Details
NCT Number NCT02339012
Lead Sponsor National Institute on Aging (NIA)
Conditions Healthy Volunteers, Non-Healthy/Non-Frail, Frail
Enrollment 900 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov