Clinical Trial

Allogeneic Stem Cell Transplant With Alpha/Beta T AND B Cell Depletion for Hematologic Malignancies

Study acronym: AB-CliniMACs
Active, Not Recruiting Phase 2
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Summary
This is a single arm pilot study for patients using α/β T cell-depleted peripheral Stem Cell Transplantation (PSCT) in with alternative donor sources with hematologic malignancies receiving alternative donor (unrelated or partially matched related) mobilized peripheral stem cells (PSCs) using the CliniMACS system for T cell depletion plus CD19+ B cell depletion to determine efficacy as determined by engraftment and graft versus host disease (GVHD), and one year leukemia free survival.
Protocol Amendment History 16 amendments
This ClinicalTrials.gov record has been amended 16 times since 2014-12-23; most recent amendment 2025-10-29.
Status change: Recruiting → Active, Not Recruiting 2024-12-31
Trial Details
NCT Number NCT02323867
Lead Sponsor Children's Hospital of Philadelphia
Conditions Leukemia, Lymphoma, Myelodysplasia
Enrollment 140 participants
Start Date 2014-10
Primary Completion 2026-10 (estimated)
Study Completion 2027-10 (estimated)
Updated on ClinicalTrials.gov 2025-10-31