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Novel Genetic Disorders of the Immune System

StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 12 months later Aug 30, 2026 → Aug 30, 2027
See other at-risk trials from National Institute of Allergy and Infectious Diseases (NIAID)

Record History

The 50 most recent of 169 record versions are accounted for below. See every version on ClinicalTrials.gov ↗

  1. Re-verified, no change to tracked fields
  2. New version filed on ClinicalTrials.gov
  3. Primary and study completion pushed from Aug 30, 2026 to Aug 30, 2027v167
  4. 11 versions Re-verified since Nov 29, 2025, no change to tracked fieldsv156-v166
  5. Primary and study completion dates: Aug 30, 2025 to Aug 30, 2026v155
Show 35 earlier versionsHide 35 earlier versions
  1. 8 versions Re-verified since Oct 2, 2024, no change to tracked fieldsv147-v154
  2. Primary and study completion dates: Aug 30, 2024 to Aug 30, 2025v146
  3. 8 versions Re-verified since Jan 5, 2024, no change to tracked fieldsv138-v145
  4. Primary completion date: Aug 31, 2023 to Aug 30, 2024v137
  5. 5 versions Re-verified since Sep 17, 2022, no change to tracked fieldsv132-v136
  6. Study Status, Contacts/Locationsv131
  7. 11 versions Re-verified since Jun 17, 2022, no change to tracked fieldsv120-v130
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Background: \- The immune system helps the body fight infection and disease. People with immune system problems can get infections, blood disorders, and other health problems. Researchers want to learn more about the immune system, like what causes it to not work properly. Objectives: \- To evaluate people with certain types of immune system disorders. Eligibility: \- Adults and children with an immune disorder or symptoms of one, and their relatives. Some disorders are not included in this study. Design: * Researchers will review participants medical records. * Participants may mail in a blood or saliva sample, or be evaluated at the clinic. At the clinic, they may have a medical history, physical exam, blood tests, and imaging scans (with dye given through a needle in the arm). They may have genetic testing done on a sample of blood, saliva, hair, or nail clipping. * Participants may choose to have a skin biopsy. Up to 2 skin samples will be taken from their arm, back, or other area. A biopsy punch is inserted into the skin and rotated. A small circle of skin is removed. * Participants 10 and older may also choose to have leukapheresis. Blood is taken through a needle in one arm. It passes through a machine that separates the white blood cells. The rest of the blood is returned by needle in the other arm. * Researchers may recommend medicines, but no treatments are being studied. * Participants may be invited to return for visits over several years. At those visits, they may repeat some or all of the above tests. Or they may mail in blood or other samples. They may also send medical records.
Trial Details
NCT Number NCT02257892
Lead Sponsor National Institute of Allergy and Infectious Diseases (NIAID)
Conditions PI3KCD, CTLA4, STAT3GOF, MAGT1
Enrollment 500 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov