Using MRI To Detect Soft Tissue Reactions And Implant Integration As Related To Implant Modularity

Patients with a total hip replacement may require early revision surgery due to an adverse local tissue reaction or bone resorption that occurs due to wear debris released from the implant. MRI provides a non-invasive biomarker for clinicians and surgeons to detect early adverse synovial reactions which may exist in the absence of clinical symptoms, thus imparting essential information for clinical management. This study will address two of the most commons causes of hip implant failure, including adverse local tissue reaction in implants not traditionally associated with adverse tissue reactions, as well as the presence of aseptic loosening and loss of implant-bone integration.

NCT Number	NCT02255331
Lead Sponsor	Hospital for Special Surgery, New York Collaborators: Medical College of Wisconsin
Conditions	Complications; Arthroplasty, Complications; Arthroplasty, Mechanical
Enrollment	240 participants
Start Date	2017-09-15
Primary Completion	2027-05 (estimated)
Study Completion	2028-05 (estimated)
Updated on ClinicalTrials.gov	2026-07-29