Clinical Trial

Phase II Trial of Radical Pleurectomy With or Without Intraoperative PDT for Malignant Pleural Mesothelioma

Study acronym: MPM-PDT
Active, Not Recruiting Phase 2
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Summary
A randomized Phase II trial to test whether the addition of intraoperative Photofrin-mediated photodynamic therapy to radical pleurectomy and post-operative chemo.improves OS in the treatment of patients with epithelioid MPM. Subjects assigned to the PDT arm will be given the photosensitizer prior to surgery . All subjects will receive maximal surgical debulking. Subjects in the PDT arm will receive intraoperative treatment using real-time, isotropic light dosimetry.
Protocol Amendment History 19 amendments
This ClinicalTrials.gov record has been amended 19 times since 2014-06-02; most recent amendment 2025-12-24.
Status change: Recruiting → Active, Not Recruiting 2024-12-09
Status change: Suspended → Recruiting 2021-05-18
Status change: Active, Not Recruiting → Suspended 2020-04-22
Status change: Recruiting → Active, Not Recruiting 2020-04-02
Trial Details
NCT Number NCT02153229
Lead Sponsor Abramson Cancer Center at Penn Medicine
Conditions Epitheliod Malignant Pleural Mesothelioma
Enrollment 52 participants
Start Date 2014-06-02
Primary Completion 2026-12-16 (estimated)
Study Completion 2027-12 (estimated)
Updated on ClinicalTrials.gov 2025-12-26