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Physical Activity as Intervention Against Age-related Loss of Muscle Mass and Function

Study acronym: LISA
StatusActive, Not Recruiting
PhaseNot applicable
Started
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Record History

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  1. Trial status: Recruiting to Active, Not Recruiting
    • Enrollment target: estimated 450 to confirmed 451
    • Site details revised
    v6
  2. Primary and study completion dates: Jun 2019 to Jun 2028v5 Show 4 more changesShow less
    • Secondary endpoints: 15 to 16
    • Study description revised
    • Site contact updated
    • Collaborators: 1 to 2
  3. Re-verified, no change to tracked fieldsv4
  4. Interventions: Control (Biological), Heavy resistance training (Procedure), Moderate intensity training (Biological), Physical activity level (Behavioral) to Control (Other), Heavy resistance training (Other), Moderate intensity training (Other)
    • Study description expanded, about 447 words
    • Site contact updated
    v3
  5. Trial status: Not Yet Recruiting to Recruiting
    • Start date: May 2014 to Apr 2014
    • Site details revised
    v2
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
A minimum of 450 healthy individuals (62-70 years old) will be recruited. Each individual will be randomized into one of three groups stratified according to gender (M/F), BMI (≤28/\>28), and 30 sec chair stand (≤11/\>11). The three groups are Heavy resistance training (n=150), moderate intensity training (n=150), and control (n=150, no training). Assessments will be performed at baseline, after 12 months of intervention. Furthermore, follow up will be performed after 2,4,7, and 10 years. The primary outcome is change in leg extensor power after the intervention and during follow up. The primary hypothesis is that by applying the intention-to-treat analysis, the moderate intensity training group will increase leg extensor power just as much as the heavy resistance training group. The two training groups will increase muscle power more than the control group.
Trial Details
NCT Number NCT02123641
Lead Sponsor Bispebjerg Hospital
Collaborators: University of Copenhagen, Hvidovre University Hospital
Conditions
(from sponsor)		 Muscle Weakness, Muscle Loss, Sarcopenia, Physical Activity
Related terms Motor Activity, Muscle Weakness, Muscular Atrophy, Sarcopenia
Enrollment 451 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov