The investigators hypothesis is that for ICU patients with shock, the use of the vasoactive drugs phenylephrine and vasopressin will reduce tachydysrhythmias when compared to norepinephrine and epinephrine. To investigate this hypothesis, the investigators are conducting a randomized double blind controlled trial comparing phenylephrine and vasopressin vs. norepinephrine and epinephrine in ICU patients with shock that is not responsive to IV fluids. All patients admitted to the adult intensive care units at the University of Chicago will be screened for eligibility.
Protocol Amendment History
13 amendments
This ClinicalTrials.gov record has been amended 13 times since 2014-04-16; most recent amendment 2026-01-12.
Status change: Not Yet Recruiting → Recruiting2014-05-27