Clinical Trial

Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease

Study acronym: IPSG1
Enrolling by Invitation
View on ClinicalTrials.gov →
Summary
Legg-Calvé-Perthes disease is a childhood hip disorder which is common enough to be a significant public health problem (affects 1 in 740 boys between ages 0-14), but uncommon enough to have a sufficient number of patients from a single institution to perform a definitive prospective study comparing the results of current treatments. The present study will establish a database of prospectively identified patients with Legg-Calvé-Perthes (LCP) Disease and collect information regarding their presentation, treatment, and outcomes in the course of receiving currently available treatments. This study seeks to compare the outcomes of current treatments in the management of different age groups (ages 1-6, 6-8, 8-11, \>11) of patients with Perthes disease at two- and five-year followup and at skeletal maturity. For each age group, two to three common treatment regimens currently used by practicing pediatric orthopaedic surgeons will be compared. The intervention a patient receives is determined through physician treatment expertise, and is not pre-determined by the study.
Protocol Amendment History 13 amendments
This ClinicalTrials.gov record has been amended 13 times since 2014-01-15; most recent amendment 2025-05-02.
Status change: Recruiting → Enrolling by Invitation 2021-10-15
Trial Details
NCT Number NCT02040714
Lead Sponsor Texas Scottish Rite Hospital for Children
Collaborators: Alberta Children's Hospital, Alfred I. duPont Hospital for Children, Le Bonheur Children's Hospital, Children's Hospital Colorado, Children's Hospital Los Angeles, Children's National Research Institute, Children's Healthcare of Atlanta, Children's Hospital of Philadelphia, Children's Hospital Medical Center, Cincinnati, Columbia University, Connecticut Children's Medical Center, Gillette Children's Specialty Healthcare, Boston Children's Hospital, Johns Hopkins University, Kaiser Permanente, Kasturba Medical College, Montefiore Medical Center, Nationwide Children's Hospital, NYU Langone Health, OrthoCarolina Research Institute, Inc., University of Sao Paulo General Hospital, Seoul National University Childrens Hospital, Shriners Hospitals for Children, University Hospital Southampton NHS Foundation Trust, Baylor College of Medicine, Universitätsklinikum Hamburg-Eppendorf, Ann & Robert H Lurie Children's Hospital of Chicago, British Columbia Children's Hospital, Children's of Alabama, Hospital Infantil Universitario Niño Jesús, Madrid, Spain, University of Oklahoma, Oregon Health and Science University, Rady Children's Hospital, San Diego, San Jorge Children's Hospital (Puerto Rico), University College Dublin, Tianjin Children's Hospital, University Hospital Schleswig-Holstein, University of California, San Francisco, University of Haifa, Uppsala University, Medical University of Lodz, Oslo University Hospital, Seattle Children's Hospital, Mayo Clinic
Conditions Legg Calve Perthes Disease
Enrollment 1,500 participants
Start Date 2012-08
Primary Completion 2032-09 (estimated)
Study Completion 2032-09 (estimated)
Updated on ClinicalTrials.gov 2025-05-06