Clinical Trial

Effects of Brain Beta-Amyloid on Postoperative Cognition

Active, Not Recruiting Phase 4
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Record status
This record was last updated May 1, 2025 (before its estimated June 2026 completion). Its status may not reflect the trial's current state.
Summary
Postoperative cognitive decline (POCD) affects up to 50% of non-cardiac surgical patients greater than or equal to 65 years of age. This study will test the hypothesis that preoperative presence of brain beta-amyloid plaques in non-demented subjects increases postoperative cognitive decline (POCD) in elderly subjects scheduled for hip or knee replacement. The investigators hypothesize that preoperative beta-amyloid plaques will predict postoperative cognitive decline.
Protocol Amendment History 13 amendments
This ClinicalTrials.gov record has been amended 13 times since 2012-05-24; most recent amendment 2025-04-28.
Status change: Recruiting → Active, Not Recruiting 2025-04-28
Trial Details
NCT Number NCT01606488
Lead Sponsor University of California, San Francisco
Collaborators: Alzheimer's Drug Discovery Foundation, Avid Radiopharmaceuticals
Conditions Postoperative Cognitive Dysfunction
Enrollment 66 participants
Start Date 2012-05
Primary Completion 2026-06 (estimated)
Study Completion 2026-06 (estimated)
Updated on ClinicalTrials.gov 2025-05-01