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Cell Collection to Study Eye Diseases

StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Record History

The 50 most recent of 431 record versions are accounted for below. See every version on ClinicalTrials.gov ↗

  1. Re-verified, no change to tracked fields
  2. Eligibility criteria expanded, about 35 words
  3. 11 versions Re-verified since Jun 18, 2026, no change to tracked fieldsv419-v429
  4. Study description revisedv418
  5. 19 versions Re-verified since Dec 10, 2025, no change to tracked fieldsv399-v417
Show 17 earlier versionsHide 17 earlier versions
  1. Study Status, Eligibilityv398
  2. 3 versions Re-verified since Nov 26, 2025, no change to tracked fieldsv395-v397
  3. Study Status, Study Description, Eligibilityv394
  4. 12 versions Re-verified since May 31, 2025, no change to tracked fieldsv382-v393
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Background: \- Best Vitelliform Dystrophy (Best disease), Late-Onset Retinal Degeneration (L-ORD), and Age-Related Macular Degeneration (AMD) all affect the retina, the light sensing area at the back of the eye. Doctors cannot safely obtain retinal cells to study these diseases. However, cells collected from hair follicles, skin, saliva, urine, and blood can be used for research. Researchers want to collect cells from people with Best disease, L-ORD, and AMD, and compare their cells with those of healthy volunteers. Objectives: \- To collect hair, skin, saliva, urine, and/or blood samples to study three eye diseases that affect the retina: Best disease, L-ORD, and AMD. Eligibility: * Individuals affected with ocular condition is one year of age or older. * Individuals affected with Best disease, L-ORD, or AMD is 18 years of age or older. * Unaffected individuals are seven years of age or older. Design: * The study requires one visit to the National Eye Institute. * Participants will be screened with a medical and eye disease history. They may also have an eye exam. * Participants will provide a hair sample, saliva sample, urine sample, blood sample, and/or a skin biopsy. The hair will be collected from the back of the head, and the skin will be collected from the inside of the upper arm.
Trial Details
NCT Number NCT01432847
Lead Sponsor National Eye Institute (NEI)
Conditions
(from sponsor)		 Retinal Disease, AMD, Retinal Degeneration, Retinitis Pigmentosa
Related terms Late-Onset Retinal Degeneration, Macular Degeneration, Retinal Degeneration, Retinal Diseases, Retinitis Pigmentosa, Vitelliform Macular Dystrophy
Enrollment 930 participants
Start Date
Updated on ClinicalTrials.gov