Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2

Study acronym: INC-6602
StatusRecruiting
PhaseNot specified
Started

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Trial flagged as At Risk
Primary completion moved at least 3 years 11 months later Dec 2026 → Dec 2030
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Record History

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  1. Primary and study completion pushed from Dec 2026 to Dec 2030 Show 4 more changesShow less
    • Study sites: 22 to 24
    • Eligibility criteria shortened, about 92 words
    • Collaborators: details revised at 8 of 22 entries
    • Publications: details revised at 1 of 1 entry
  2. Study sites: 17 to 22v15
  3. Primary and study completion dates: Dec 2024 to Dec 2026
    • Study sites: 19 to 17
    • Eligibility criteria shortened, about 103 words
    • Collaborators: 17 to 22
    v14
  4. Primary and study completion dates: Dec 2022 to Dec 2024v13
  5. Primary and study completion dates: Apr 2021 to Dec 2022v12
Show 10 earlier versionsHide 10 earlier versions
  1. Primary and study completion dates: Dec 2019 to Apr 2021
    • Study sites: 20 to 19
    • Start date: Apr 2010 to May 2010
    • Collaborators: 16 to 17
    v11
  2. Site details revised at 1 of 20 sitesv10
  3. Study sites: 22 to 20v9
  4. Primary completion date: Dec 2016 to Dec 2019
    • Study sites: 14 to 22
    • Study completion date: Dec 2019
    • Collaborators revised (16)
    v8
  5. Primary completion date: Dec 2015 to Dec 2016
    • Study sites: 9 to 14
    • Collaborators: 10 to 16
    v7
  6. Site contacts updated at 1 of 9 sitesv6
  7. Lead sponsor: Wayne State University to University of Iowav5 Show 4 more changesShow less
    • Primary completion date: Dec 2015
    • Study description expanded, about 77 words
    • Study sites revised (9)
    • Collaborators revised (10)
  8. Primary endpoints revised (2)
    • Study sites: 6 to 9
    • Eligibility criteria expanded, about 81 words
    • Collaborators: 8 to 10
    v4
  9. Eligibility criteria shortened, about 5 wordsv3
  10. Eligibility criteria expanded, about 16 wordsv2
  1. Study First Submitted
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This project includes two projects. One is looking for new genes that cause Charcot Marie Tooth disease (CMT). The other is looking for genes that do not cause CMT, but may modify the symptoms a person has.
Trial Details
NCT Number NCT01193088
Lead Sponsor University of Iowa
Collaborators: National Institute of Neurological Disorders and Stroke (NINDS), Muscular Dystrophy Association, University of Rochester, University of Pennsylvania, King's College Hospital NHS Trust, Sydney Children's Hospitals Network, Children's Hospital of Philadelphia, University of Miami, Johns Hopkins University, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Cedars-Sinai Medical Center, Nemours Children's Clinic, Stanford University, University of Minnesota, Massachusetts General Hospital, University of Colorado, Denver, Children's National Research Institute, University of Michigan, St. Jude Children's Research Hospital, Connecticut Children's Medical Center, Seattle Children's Hospital, The Hospital for Sick Children
Conditions
(from sponsor)		 Charcot-Marie-Tooth Disease, Type Ia (Disorder), HMSN
Related terms Charcot-Marie-Tooth Disease, Hereditary Sensory and Motor Neuropathy
Enrollment 1,050 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov