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Genetic Epidemiology of Ovarian Aging

StatusCompleted
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Record History

  1. Trial status: Active, Not Recruiting to Completed Enrollment target: estimated 1250 to confirmed 1080 · Primary and study completion dates changed from estimate of Jul 2025 to Jul 31, 2012v17 Show 2 more changesShow less
    • Enrollment target: estimated 1250 to confirmed 1080
    • Primary and study completion dates changed from estimate of Jul 2025 to Jul 31, 2012
  2. Primary completion date: Dec 2023 to Jul 2025 Completion date: Jul 2024 to Jul 2025v16 Show 1 more changeShow less
    • Completion date: Jul 2024 to Jul 2025
  3. Primary completion date: Jul 2023 to Dec 2023 Completion date: Dec 2023 to Jul 2024v15 Show 1 more changeShow less
    • Completion date: Dec 2023 to Jul 2024
  4. Primary completion date: Jul 2021 to Jul 2023 Completion date: Dec 2021 to Dec 2023v14 Show 1 more changeShow less
    • Completion date: Dec 2021 to Dec 2023
  5. Re-verified, no change to tracked fieldsv13
Show 11 earlier versionsHide 11 earlier versions
  1. Primary completion date: Jul 2020 to Jul 2021 Completion date: Dec 2020 to Dec 2021 · Study description expanded, about 5 wordsv12 Show 2 more changesShow less
    • Completion date: Dec 2020 to Dec 2021
    • Study description expanded, about 5 words

    See this version in full on ClinicalTrials.gov ↗

  2. Re-verified, no change to tracked fieldsv11
  3. Primary completion date: Dec 2014 to Jul 2020 Completion date: Dec 2014 to Dec 2020v10 Show 1 more changeShow less
    • Completion date: Dec 2014 to Dec 2020
  4. Primary completion date: Dec 2014 Completion date: Mar 2013 to Dec 2014v9 Show 1 more changeShow less
    • Completion date: Mar 2013 to Dec 2014
  5. Study sites: 2 to 1 Completion date: Mar 2012 to Mar 2013v8 Show 1 more changeShow less
    • Completion date: Mar 2012 to Mar 2013
  6. Completion date: Mar 2011 to Mar 2012v7
  7. Trial status: Enrolling by Invitation to Active, Not Recruiting Completion date: Mar 2010 to Mar 2011v6 Show 1 more changeShow less
    • Completion date: Mar 2010 to Mar 2011
  8. Trial status: Recruiting to Enrolling by Invitation Site details revised at 2 of 2 sitesv5 Show 1 more changeShow less
    • Site details revised at 2 of 2 sites
  9. Study Status, Arms and Interventionsv4
  10. 2 versions Re-verified since Jul 16, 2007, no change to tracked fieldsv2-v3
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The purpose of this study is to identify clinical and genetic markers of ovarian aging. In this process, we will evaluate environmental factors that may affect fertility and the age at which fertility declines, and may influence the age at which women enter menopause. Wide variability exists between women both in the age at which menopause occurs and the rate of decline in oocyte number and reproductive capability. As the loss of ovarian function has profound impact on women's hormonal milieu and their subsequent risk for the development of disease, improving our understanding of the factors that determine the timing and rate of reproductive aging is critical to improving quality of life for all women. In addition, improving our understanding of reproductive aging has profound economic, and social, implications given the complex choices women face regarding the timing of childbearing and the growing burden of infertility. While the inter-individual variability in age at menopause has a large genetic component and possible environmental influences, to date no studies have addressed the relationship between oocyte number as reflected by antral follicle count (AFC) and genetic inheritance. We hypothesize that ovarian aging, as reflected by antral follicle count, is largely determined by common genetic polymorphisms that impact the initial oocyte endowment and/or the rate of oocyte loss over time thus lowering antral follicle count for any given age. We further hypothesize that antral follicle count will be an improved marker of ovarian aging. Thus, we propose a study of the genetic and environmental factors that influence age-specific variability in antral follicle count.
Trial Details
NCT Number NCT00501800
Lead Sponsor University of California, San Francisco
Collaborators: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Aging (NIA), Kaiser Foundation Research Institute, Stanford University, University of Michigan
Conditions Infertility
Enrollment 1,080 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov