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Evaluation of Patients With Immune Function Abnormalities

StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Amendment history

The 50 most recent of 313 record versions are accounted for below. See every version on ClinicalTrials.gov ↗

  1. Notable

    Primary endpoints: details revised at 1 of 4 entries

    Eligibility criteria expanded, about 19 words; Study description expanded, about 3 words; Publications: details revised at 6 of 6 entries

    Show what changed: Eligibility criteria
    * INCLUSION CRITERIA: Patients: To be eligible to participate [...] a patient, an individual must meet the following criteria: * Must be 2 years of age to be seen at the Clinical Center as [...] ections. Send-in samples for clinical diagnosis at any age. * Have an abnormality of immune function as manifested by: * recurrent or unusual infections, * recurrent or chronic inflammation, or * previous laboratory evidence of immune dysfunction. * Have a primary physician outside of the NIH. Relatives of Pa [...] t relative, an individual must meet the following criteria: * Be a biological mother, father, sibling, chi [...] [...]
    Show what changed: Study description
    [...] abnormalities of immune function with the following goals: 1. To determine the degree, scope, and cause of immune dysfunction; 2. To establish the pace and pattern of change in the disease process; 3. To determine the extent of organ involvement and damage from [...]

  2. Minor

    49 amendments

    49 re-verifications since 2024-09-18, no change to tracked fields

    v264-v312

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation. This may include inherited conditions, such as X-linked severe combined immunodeficiency (XSCID), chronic granulomatous disease (CGD), and leukocyte adhesion deficiency (LAD), or conditions resulting from outside factors, such as graft-versus-host disease (GVHD). The information from this study will be used to establish the pattern and pace of change of the disease and to help develop new treatments. The period of observation and study following enrollment in this study may be for up to one year. In addition these studies may provide the medical information needed to determine eligibility for enrollment in other clinical study protocols and more prolonged follow up. Patients of any age with abnormal immune function who have recurrent or unusual infections, whose blood tests show evidence of immune dysfunction, or who have GVHD, XSCID, CGD or LAD may be eligible for this study. Patients' parents, siblings, grandparents, children, aunts, uncles and first cousins of any age also may be included. Healthy normal volunteers between 18 and 85 years of age are recruited as controls. Normal volunteers undergo a physical examination and provide blood, saliva, and urine samples for immune function studies. Patients' family members provide a medical history, have a physical examination, and give blood and urine samples, and possibly a saliva sample. The samples are used for genetic and routine laboratory studies. Investigators may request tissue samples, such as biopsy specimens, previously removed for medical reasons to be sent to NIH for study. Patients undergo the following tests and procedures: 1. Medical history and physical examination. 2. Blood and urine tests, including analysis for genes involved in immune disorders. 3. Buccal smear (in some patients) for genetic studies. This involves scraping the lining of the mouth near the cheek. 4. Specialized tests to evaluate specific conditions in patients who have an immune disorder that might affect lung function, gum infections or eye problems. These may include chest x-ray, CT scan, breathing function test, dental, eye, and hearing examinations. 5. Follow-up visits of patients with immune problems may occur at 6 months and at one year after the first visit (or more frequently if medically required) to include: * Medical history update * Physical examination * Follow-up on abnormal test results and medical treatments initiated at NIH * Collection of blood, saliva, urine, or wound drainage samples for repeat immune function studies * Tissue study of specimens removed for medical reasons at other institutions besides NIH
Trial Details
NCT Number NCT00128973
Lead Sponsor National Institute of Allergy and Infectious Diseases (NIAID)
Conditions Chronic Granulomatous Disease (CGD), X-Linked Severe Combined Immune Deficiency (XSCID), Leukocyte Adhesion Deficiency 1 (LAD), Graft Versus Host Disease (cGvHD)
Enrollment 3,500 participants
Start Date
Updated on ClinicalTrials.gov