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Genetic Basis of Immunodeficiency

StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Amendment history

The 50 most recent of 395 record versions are accounted for below. See every version on ClinicalTrials.gov ↗

  1. Minor

    Re-verified, no change to tracked fields

  2. Minor

    Eligibility criteria expanded, about 8 words

    Publications: details revised at 3 of 3 entries

    Show what changed: Eligibility criteria
    * INCLUSION CRITERIA: Index cases to be included are those wit [...] ells. Relatives of affected individuals may also be studied * Patients (index cases): 6 months of age and older * Siblings: 6 months of age and older * Non-sibling relatives (biological parent, aunt, uncle or grandparent): 18 years or older EXCLUSION CRITERIA: * Patients with a known diagnosis * Patients with a particular immunological phenotype that is not of interest to the research conducted under this study. * Pregnancy or lactation * Adults with current decisional impairment

  3. Minor

    48 amendments

    48 re-verifications since 2025-04-05, no change to tracked fields

    v346-v393

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study will examine the role of hereditary factors in different forms of severe combined immunodeficiency (SCID). Patients with immunodeficiencies may be eligible for this study. Candidates include: * Patients with diminished numbers of T cells or NK cells or both, or * Patients with normal T cell and NK cell numbers but diminished T cell, B cell, or NK cell function. Relatives of patients will also be studied. Participants will have blood samples collected for genetic analysis in studies related to SCID at the National Institutes of Health and other institutions.
Trial Details
NCT Number NCT00055172
Lead Sponsor National Heart, Lung, and Blood Institute (NHLBI)
Conditions Severe Combined Immunodeficiency
Enrollment 100 participants
Start Date
Updated on ClinicalTrials.gov