Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT00044122 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

Study of Factors Regulating Mast Cell Proliferation

StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Record History

The 50 most recent of 312 record versions are accounted for below. See every version on ClinicalTrials.gov ↗

  1. Re-verified, no change to tracked fields
  2. Re-verified, no change to tracked fields
  3. Eligibility criteria expanded, about 1 word
  4. Re-verified, no change to tracked fieldsv309
  5. Enrollment increased: 600 → 700 participantsv308
Show 45 earlier versionsHide 45 earlier versions
  1. 4 versions Re-verified since Jul 31, 2026, no change to tracked fieldsv304-v307
  2. Study Status, Eligibilityv303
  3. 40 versions Re-verified since Jun 7, 2025, no change to tracked fieldsv263-v302
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study will examine growth factors that promote and inhibit mast cell proliferation resulting in mastocytosis, a disease of excessive mast cells in the body. These cells can release chemicals that cause itching, blisters, flushing, bone pain and abdominal pain. Patients up to 80 years of age with mastocytosis may be eligible for this 1-day study. Participants will have one visit at NIH lasting up to 8 hours, during which they will undergo the following tests and procedures: * Medical history and physical examination. * Laboratory studies, if medically indicated. * Blood tests to identify genetic changes important in the growth, development, and functioning of mast cells. * Bone marrow aspiration and biopsy. For the bone marrow procedure, the skin over the hipbone and the outer surface of the bone itself are numbed with local anesthesia. Then, a special needle is inserted into the hipbone and about 1 tablespoon of bone marrow is drawn into a syringe. Another needle is inserted into the same area to collect a small piece of the bone marrow. Additional procedures may include allergen testing, urinalysis, and 24-hour urine collection. Participants will receive an evaluation of their mastocytosis.
Trial Details
NCT Number NCT00044122
Lead Sponsor National Institute of Allergy and Infectious Diseases (NIAID)
Conditions Mastocytosis, Monoclonal, Bone Marrow, Tryptase
Enrollment 700 participants
Start Date
Updated on ClinicalTrials.gov