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Study of Inherited Neurological Disorders

StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Amendment history

The 50 most recent of 365 record versions are accounted for below. See every version on ClinicalTrials.gov ↗

  1. Minor

    Re-verified, no change to tracked fields

  2. Minor

    Re-verified, no change to tracked fields

  3. Minor

    Eligibility criteria expanded, about 4 words

    Show what changed: Eligibility criteria
    * Participants include those with inherited neurological condi [...] INCLUSION CRITERIA: Participants will be eligible if they: * Have either a known or suspected, inherited neurological dis [...] tive) of a participant with a genetic neurological disease. * Have the ability to understand and sign an informed consent [...] ian to provide consent for adults without consent capacity. * Aged 2 years and above. EXCLUSION CRITERIA: Participants wil [...]

  4. Minor

    Study Status

    Re-verified, no change to tracked fields

    v362

  5. Minor

    Eligibility criteria expanded, about 1 word

    Study description expanded, about 5 words

    Show what changed: Eligibility criteria
    [...] ogenetics Branch program. There is no logical limit; however, the total number of participants that can be enrolled in th [...]
    Show what changed: Study description
    [...] , blood or other biologic samples (including urine, saliva, or a cheek (buccal) swab, skin biopsy and muscle biopsy) will be obtained for future laboratory studies. STUDY POPU [...] iagnostic study of multiple neurological diseases and their progression and pathophysiology. OUTCOME MEASURES: No formal outcomes will be measured; however, the clinical assessments of enrolled participants can be us [...]

    Study Status, Study Description, Eligibility, Contacts/Locationsv361

  6. Minor

    45 amendments

    45 re-verifications since 2024-08-23, no change to tracked fields

    v316-v360

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study is designed to learn more about the natural history of inherited neurological disorders and the role of heredity in their development. It will examine the genetics, symptoms, disease progression, treatment, and psychological and behavioral impact of diseases in the following categories: hereditary peripheral neuropathies; hereditary myopathies; muscular dystrophies; hereditary motor neuron disorders; mitochondrial myopathies; hereditary neurocognitive disorders; inherited neurological disorders without known diagnosis; and others. Many of these diseases, which affect the brain, spinal cord, muscles, and nerves, are rare and poorly understood. Children and adults of all ages with various inherited neurological disorders may be eligible for this study. Participants will undergo a detailed medical and family history, and a family tree will be drawn. They will also have a physical and neurological examination that may include blood test and urine tests, an EEG (brain wave recordings), psychological tests, and speech and language and rehabilitation evaluations. A blood sample or skin biopsy may be taken for genetic testing. Depending on the individual patient's symptoms, imaging tests such as X-rays, CT or MRI scans and muscle and nerve testing may also be done. Information from this study may provide a better understanding of the genetic underpinnings of these disorders, contributing to improved diagnosis, treatment, and genetic counseling, and perhaps leading to additional studies in these areas.
Trial Details
NCT Number NCT00004568
Lead Sponsor National Institute of Neurological Disorders and Stroke (NINDS)
Conditions Motor Neuron Disease, Muscular Disease, Muscular Dystrophy, Peripheral Nervous System Disease
Enrollment 3,500 participants
Start Date
Updated on ClinicalTrials.gov