| Detected | Trial | Change |
|---|---|---|
| 2026-08-11 | NCT03406611 Pegtibatinase as a Treatment for Patients With Classical Homocystinuria (HCU) (Also Known… |
Enrollment reopened |
| 2026-08-11 | NCT03406611 Pegtibatinase as a Treatment for Patients With Classical Homocystinuria (HCU) (Also Known… |
Primary endpoint(s) modified |
| 2026-08-11 | NCT03406611 Pegtibatinase as a Treatment for Patients With Classical Homocystinuria (HCU) (Also Known… |
Enrollment increased: 32 -> 39 participants |
| 2026-08-11 | NCT03406611 Pegtibatinase as a Treatment for Patients With Classical Homocystinuria (HCU) (Also Known… |
Trial arms changed: 2 -> 3 |
| 2026-08-11 | NCT03406611 Pegtibatinase as a Treatment for Patients With Classical Homocystinuria (HCU) (Also Known… |
Trial sites expanded: 8 -> 12 locations |
| 2026-08-11 | NCT03406611 Pegtibatinase as a Treatment for Patients With Classical Homocystinuria (HCU) (Also Known… |
date change Primary completion pushed: 2026-06 -> 2027-07 |
| 2026-08-11 | NCT03406611 Pegtibatinase as a Treatment for Patients With Classical Homocystinuria (HCU) (Also Known… |
date change Completion pushed: 2026-12 -> 2027-07 |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 4 | |||
| NCT07219121 | Sparsentan in Posttransplant Immunoglobulin A Nephropathy or Focal Segmental… | Proteinuria | Active, Not Recruiting |
| Phase 3 | |||
| NCT06247085 | A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in… | Homocystinuria | Recruiting |
| NCT03762850 | A Study of the Effect and Safety of Sparsentan in the Treatment of Patients With IgA… | Immunoglobulin A Nephropathy | Active, Not Recruiting |
| NCT06431893 | A Long-term Extension Study to Assess the Long-term Safety and Efficacy of Pegtibatinase… | Homocystinuria | Enrolling by Invitation |
| Phase 2 | |||
| NCT05003986 | Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases | Focal Segmental Glomerulosclerosis | Recruiting |
| Phase 1/2 | |||
| NCT03406611 | Pegtibatinase as a Treatment for Patients With Classical Homocystinuria (HCU) (Also Known… | Homocystinuria | Recruiting |
| Not specified | |||
| NCT02998710 | Natural History Study of Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency… | Homocystinuria Due to CBS Deficiency | Recruiting |