| Detected | Trial | Change |
|---|---|---|
| 2026-08-01 | NCT06708897 A Study of Lonitoclax (ZE50-0134) in Relapsed or Refractory B-cell Malignancies |
Primary endpoint(s) modified |
| 2026-08-01 | NCT06708897 A Study of Lonitoclax (ZE50-0134) in Relapsed or Refractory B-cell Malignancies |
Enrollment increased: 66 -> 84 participants |
| 2026-08-01 | NCT06708897 A Study of Lonitoclax (ZE50-0134) in Relapsed or Refractory B-cell Malignancies |
Trial arms changed: 8 -> 12 |
| 2026-08-01 | NCT06708897 A Study of Lonitoclax (ZE50-0134) in Relapsed or Refractory B-cell Malignancies |
date change Primary completion pushed: 2026-03 -> 2028-01 |
| 2026-08-01 | NCT06708897 A Study of Lonitoclax (ZE50-0134) in Relapsed or Refractory B-cell Malignancies |
date change Completion pushed: 2028-04 -> 2028-07 |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 1 | |||
| NCT06366789 | Dose Escalation and Expansion Study to Evaluate the Safety, PK, PD and Efficacy of… | AML With Gene Mutations | Recruiting |
| NCT06708897 | A Study of Lonitoclax (ZE50-0134) in Relapsed or Refractory B-cell Malignancies | CLL / SLL | Recruiting |
| NCT07303660 | A Phase 1b Study of Lonitoclax + Azacitidine in Acute Myeloid Leukemia Patients | Acute Myeloid Leukemia | Not Yet Recruiting |