| Detected | Trial | Change |
|---|---|---|
| 2026-05-29 | NCT07232589 A Study of the Effect of Diltiazem on the Plasma Levels of Nemtabrutinib (MK-1026-022) |
Trial completed |
| 2026-05-23 | NCT05458297 A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in… |
Primary endpoint(s) modified |
| 2026-05-23 | NCT05458297 A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in… |
Enrollment reduced: 223 -> 189 participants |
| 2026-05-23 | NCT05458297 A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in… |
Trial arms changed: 5 -> 4 |
| 2026-05-21 | NCT06863402 Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse… |
date change Primary completion pushed: 2029-04-01 -> 2029-06-01 |
| 2026-05-21 | NCT06863402 Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse… |
date change Completion pushed: 2030-04-01 -> 2030-06-01 |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 3 | |||
| NCT05947851 | A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line… | Leukemia, Lymphocytic, Chronic, B-Cell | Recruiting |
| NCT06136559 | A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib… | Chronic Lymphocytic Leukemia | Recruiting |
| NCT05624554 | A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated… | Chronic Lymphocytic Leukemia | Active, Not Recruiting |
| Phase 2 | |||
| NCT06572618 | Nemtabrutinib With Rituximab for the Treatment of Patients With Mantle Cell Lymphoma | Mantle Cell Lymphoma | Recruiting |
| NCT06863402 | Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse… | Richter Syndrome | Recruiting |
| NCT04728893 | Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic… | Hematologic Malignancies | Recruiting |
| NCT07194980 | Nemtabrutinib and Lisocabtagene Maraleucel for the Treatment of Relapsed/Refractory… | Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | Recruiting |
| NCT07557056 | Nemtabrutinib and Venetoclax for the Treatment of Patients With Chronic Lymphocytic… | Chronic Lymphocytic Leukemia | Not Yet Recruiting |
| NCT07583810 | Non-covalent BTK Inhibitor Nemtabrutinib in Combination With the CD20 Monoclonal Antibody… | Conjunctival Mucosa-Associated Lymphoid Tissue Lymphoma | Not Yet Recruiting |
| NCT05458297 | A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in… | Chronic Lymphocytic Leukemia | Active, Not Recruiting |
| Phase 1 | |||
| NCT06442436 | A Study of Nemtabrutinib in Participants With Moderate Hepatic Impairment (MK-1026-015) | Hepatic Impairment (HI) | Recruiting |
| NCT05347225 | A Study of Nemtabrutinib (MK-1026) in China Participants With Relapsed or Refractory… | Hematological Malignancies | Active, Not Recruiting |