| Detected | Trial | Change |
|---|---|---|
| 2026-06-09 | NCT06345729 A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS… |
Trial sites expanded: 222 -> 225 locations |
| 2026-06-09 | NCT06997497 A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People… |
Trial sites expanded: 192 -> 196 locations |
| 2026-06-09 | NCT07190248 A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With… |
Trial sites expanded: 170 -> 175 locations |
| 2026-06-04 | NCT07554339 A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell… |
Recruitment opened |
| 2026-06-04 | NCT07554339 A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell… |
Trial sites expanded: 0 -> 5 locations |
| 2026-06-04 | NCT07431827 MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC… |
Trial sites expanded: 24 -> 36 locations |
| 2026-05-30 | NCT07190248 A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With… |
Trial sites expanded: 160 -> 170 locations |
| 2026-05-30 | NCT06997497 A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People… |
Trial sites expanded: 187 -> 192 locations |
| 2026-05-27 | NCT07190248 A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With… |
Trial sites expanded: 156 -> 160 locations |
| 2026-05-27 | NCT06997497 A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People… |
Trial sites expanded: 180 -> 187 locations |
| 2026-05-27 | NCT07286149 A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer… |
Trial sites expanded: 12 -> 18 locations |
| 2026-05-19 | NCT07190248 A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With… |
Trial sites expanded: 153 -> 156 locations |
| 2026-05-15 | NCT06997497 A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People… |
Trial sites expanded: 161 -> 180 locations |
| 2026-05-15 | NCT07286149 A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer… |
Trial sites expanded: 4 -> 12 locations |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 3 | |||
| NCT07431827 | MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC… | Non-small Cell Lung Cancer | Recruiting |
| NCT07554339 | A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell… | Non-small Cell Lung Cancer | Recruiting |
| NCT06345729 | A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS… | Non-small Cell Lung Cancer | Recruiting |
| NCT06997497 | A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People… | Colon Adenocarcinoma | Recruiting |
| NCT07190248 | A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With… | Non-small Cell Lung Cancer | Recruiting |
| Phase 2 | |||
| NCT07252739 | KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With… | Malignant Neoplasm | Recruiting |
| NCT07209111 | A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors… | Neoplasm Malignant | Recruiting |
| Phase 1/2 | |||
| NCT07286149 | A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer… | Lung Neoplasm Malignant | Recruiting |
| Phase 1 | |||
| NCT07219550 | A Study of Calderasib (MK-1084) in Participants With Hepatic Impairment and Healthy… | Healthy | Recruiting |
| NCT05853367 | Study of MK-0472 in Participants With Advanced/Metastatic Solid Tumors (MK-0472-001) | Metastatic Solid Tumors | Recruiting |
| NCT05067283 | A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001) | Advanced Solid Tumors | Recruiting |