Also listed under Colonic Diseases, Rectal Diseases

ClinicalTrials.gov term: Colorectal Neoplasms

Disease landscape

Colorectal Cancer clinical trials

Get alerts when Colorectal Cancer trials change
Data updated daily from ClinicalTrials.gov, last refresh 2026-10-16

What changed in the last 30 days

207 trials changed in the last 30 days: 5 stopped, 90 with notable changes, 112 with minor changes only.

  1. Stopped

    NOTABLE-308 · Nimotuzumab Combined With Trifluridine/Tipiracil · Refractory Metastatic Colorectal Cancer

    Withdrawn before enrolling

    Sponsor's reason: Study withdrawn before enrollment of any participant due to a corporate strategic decision. Not related to safety or efficacy concerns.

    Biotech Pharmaceutical Co., Ltd.Phase 3 NCT06343116 Registry history of NCT06343116 on ClinicalTrials.gov (opens the registry)

    Updated

Show 112 trials with minor changes only
  1. Minor

    M3-PRO · Diagnostic Accuracy of a Panel of Bacterial Gene Markers (M3) for Colorectal Advanced Neoplasia

    Trial status changed: Unknown → Active, Not Recruiting

    Also in this update: Study completion pushed from Dec 31, 2025 to Dec 31, 2030; Primary completion date changed from estimate of Jun 15, 2025 to May 7, 2025

    Chinese University of Hong KongNot specified NCT05405673 Registry history of NCT05405673 on ClinicalTrials.gov (opens the registry)

    Updated

  2. Minor

    Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or Targeted Therapy and/or ICI, · Advanced Gastrointestinal Cancers, Including Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)

    Enrollment increased: 258 → 350 participants

    Also in this update: Interventions modified

    Phanes TherapeuticsPhase 1/2 NCT05482893 Registry history of NCT05482893 on ClinicalTrials.gov (opens the registry)

    Updated

  3. Minor

    AndroMETa-CRC · Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil · Refractory Metastatic Colorectal Cancer

    Trial sites expanded: 73 → 76 locations

    And 1 more change in the last 30 days

    AbbViePhase 3 NCT07525206 Registry history of NCT07525206 on ClinicalTrials.gov (opens the registry)

    Changed

  4. Minor

    Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone · Unresectable Colorectal Liver Metastases: The PUMP Trial

    Interventions modified

    Also in this update: Study completion moved earlier from Jun 30, 2034 to Jun 30, 2029

    ECOG-ACRIN Cancer Research GroupPhase 3 NCT05863195 Registry history of NCT05863195 on ClinicalTrials.gov (opens the registry)

    Updated

  5. Minor
    28 trials marked Unknown by the registry's verification sweep
    1. Minor

      Development and Demonstration of Intelligent Assessment Based on Multi-modal Information Fusion for Tumor Risk and Diagnosis and Treatment

      Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Recruiting

      Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyNot specified NCT06653478 Registry history of NCT06653478 on ClinicalTrials.gov (opens the registry)

      Changed

    Registry verification sweep

    Changed

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-10-15 NCT07874880 MTX-531-001 Phase 1 Study in Advanced Solid Tumors MEKanistic Therapeutics, Inc. new Phase 1
2026-10-15 NCT07875920 Phase 1 Study of NW-301V TCR-T Cells in Advanced Solid Tumors With KRAS G12V Mutation Neowise Biotechnology new Phase 1
2026-10-15 NCT07875465 Intestinal Low-Dose Radiotherapy Combined With Immune Checkpoint Inhibitors in Solid… Bing Xia new Phase 2
2026-10-14 NCT07874035 Low Load Blood Flow Restriction Resistance Training in Colorectal Cancer Related… Ahmed Adel Ahmed Elsayed Ali Radwan new
2026-10-14 NCT07873450 SumMET: Study of [225Ac]Ac-FL-261 in Participants With Solid Tumors Overexpressing c-MET Full-Life Technologies UK Limited new Phase 1/2
2026-10-07 NCT07863154 Probiotic Supplementation During Neoadjuvant Chemoradiotherapy in Colorectal Cancer University of Malaga new
2026-09-30 NCT07850778 ONS USE IN COLON CANCER Osmaniye Korkut Ata University new
2026-09-30 NCT07850882 A Prospective Real-World Observational Study of Intratumoral Oncolytic Virus Injection… Jie Yuan,MD new
2026-09-28 NCT07844187 TQB2922 Injection Given Under the Skin With Chemotherapy as Initial Treatment for… Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd. new Phase 1/2
2026-09-22 NCT07834268 Feasibility of Multi-cancer Early Detection Test in Screening Population (NQMD-CS) Fifth Affiliated Hospital of Guangzhou Medical University new

Active trials by phase

Early Phase 1
33
Phase 1
277
Phase 1/2
216
Phase 2
609
Phase 2/3
44
Phase 3
188
Phase 4
27
Not charted: 1,375 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 2,769

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT05148494 TES RCT Fleet Enema vs Oral Mechanical Bowel Prep Nova Scotia Health Authority Recruiting 2026-08-21
NCT07696793 Efficacy and Tolerability of a Simethicone-containing Evacuating Solution for Colorectal… Fundacion Clinic per a la Recerca Biomédica Recruiting 2026-07-10
NCT06562543 A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With… Takeda Recruiting 2026-07-07
NCT07209787 SIS-Reinforced vs. Conventional Anastomosis for Mid-to-Low Rectal Cancer: A Multicenter… Beijing Chao Yang Hospital Recruiting 2026-06-17
NCT05726136 Fluid Challenge and Plasma Volume, During Surgery Joachim Zdolsek Recruiting 2026-04-30
NCT04373564 Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based… Guerbet Recruiting 2026-01-22
NCT05345613 Tranexamic Acid During Colonic Endoscopic Resection Procedures Assaf-Harofeh Medical Center Recruiting 2026-01-13
NCT07158164 DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment Rutgers, The State University of New Jersey Recruiting 2025-11-13
NCT07215000 Cleansing Options in Out-Patient Setting to Improve Tolerance (COOP SIT) Trial Morehouse School of Medicine Recruiting 2025-10-09
NCT06090994 Prevention of Recurrence and Metastasis of Colorectal Cancer by Comparing Huaier With… Fudan University Recruiting 2025-05-07
NCT06935708 Intrathecal Morphine Versus Epidural Analgesia for Open Colon Surgery Meri Mirceta Recruiting 2025-04-20
NCT05894694 Survival Benefit of Compound Kushen Injection in the Treatment of Advanced Colorectal… Guang'anmen Hospital of China Academy of Chinese Medical Sciences Recruiting 2024-12-27
NCT05250648 Clinical Trial on HIPEC With Mitomycin C in Colon Cancer Peritoneal Metastases (GECOP-MMC) Hospital Universitario de Fuenlabrada Recruiting 2024-10-09
NCT05148767 UGT1A1-Based Irinotecan Therapy for Locally Advanced Rectal Cancer Zhejiang Cancer Hospital Recruiting 2021-12-08
NCT07861815 Assessing the Feasibility of Using Methylene Blue in Identifying Ureters During… Chinese University of Hong Kong Not Yet Recruiting 2026-10-06
NCT07802847 Innovative and Cooperative Pathway Integrating Oncogeriatric, Pharmaceutical and… Gustave Roussy, Cancer Campus, Grand Paris Not Yet Recruiting 2026-09-03
NCT07768358 Tucatinib Continuation Study Pfizer Not Yet Recruiting 2026-08-28
NCT07094893 Anti-EGFR Agents in Patients With Right-sided Advanced Colorectal Cancer With Wild-type… Gruppo Oncologico del Nord-Ovest Not Yet Recruiting 2026-07-24
NCT07624916 Transversus Abdominis Plane and Rectus Sheath Block for Robotic Colectomy Tri-Service General Hospital (TSGH) Not Yet Recruiting 2026-06-03
NCT07483060 Next Generation STAR-TREC (NG-ST) - Organ Preservation in Early Rectal Cancer Vastra Gotaland Region Not Yet Recruiting 2026-03-19
NCT07446465 FOLFOX Chemotherapy Combined With Fruquintinib and Serplulimab as First-Line Conversion… Ye Xu Not Yet Recruiting 2026-03-03
NCT07152886 The Effects of Clostridium Butyricum on Adverse Events During Adjuvant Chemotherapy for… The Affiliated Hospital of Qingdao University Not Yet Recruiting 2025-09-03
NCT07020468 Neoadjuvant Therapy (NALIRIFOX) for Locally Advanced Colon and Upper Rectal Cancer Affiliated Cancer Hospital of Shantou University Medical College Active, Not Recruiting 2025-06-13
NCT06881563 Intrathecal Morphine Versus Epidural Analgesia for Laparoscopic Colon Surgery Meri Mirceta Not Yet Recruiting 2025-03-18
NCT06784258 Comparison of Inflammatory Factors, Pain Scale, and Postoperative Recovery Quality (QOR… Udayana University Active, Not Recruiting 2025-01-20

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