Also listed under Breast Diseases

ClinicalTrials.gov term: Breast Neoplasms

Disease landscape

Breast Cancer clinical trials

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Data updated daily from ClinicalTrials.gov, last refresh 2026-10-17

What changed in the last 30 days

323 trials changed in the last 30 days: 9 stopped, 155 with notable changes, 159 with minor changes only.

  1. Stopped

    SAFIR 03 · Detection of Tumor DNA in the Blood of Patients Receiving Standard Therapy for Hormone Receptor-positive (HR+) Non-HER2 Expressing (HER2-) Metastatic Breast Cancer as a Tool to Select Those Who May Benefit From the Next Course of Fulvestrant in Combination With Alpelisib or Ribociclib

    Trial terminated

    Also in this update: Final enrollment: 4 participants — 2% of the 162 planned; Primary completion date changed from estimate of Jul 2028 to Mar 30, 2025

    UNICANCERPhase 2 NCT05625087 Registry history of NCT05625087 on ClinicalTrials.gov (opens the registry)

  2. Stopped

    SERCABOT · Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome

    Trial status changed: Recruiting → Withdrawn

    Also in this update: Start date changed from estimate of Oct 31, 2026 to Jun 10, 2025; Primary completion date changed from estimate of Aug 30, 2027 to Sep 22, 2026

    Centre Oscar LambretPhase 2 NCT06807164 Registry history of NCT06807164 on ClinicalTrials.gov (opens the registry)

  3. Stopped

    ALTERNATIVE · Telemonitoring Platform "CUREETY TECHCARE" vs Standard of Care for mTBNC Patients Initiating a First-line Treatment

    Trial terminated

    Also in this update: Final enrollment: 31 participants — 7% of the 472 planned; Primary completion date changed from estimate of Sep 1, 2026 to Dec 1, 2025

    UNICANCERNot applicable NCT06505018 Registry history of NCT06505018 on ClinicalTrials.gov (opens the registry)

  4. Notable

    NeoTILs · Biomarker-Guided De-escalation Using Anthracycline-Free Neoadjuvant Chemoimmunotherapy in Early-Stage Triple Negative Breast Cancer (TNBC) · High Tumor-Infiltrating Lymphocytes (TILs)

    Primary completion pushed from Mar 1, 2029 to Sep 22, 2029

    Also in this update: Study completion pushed from Mar 1, 2030 to May 29, 2034

    Medical University of South CarolinaPhase 2 NCT07743190 Registry history of NCT07743190 on ClinicalTrials.gov (opens the registry)

Show 159 trials with minor changes only
  1. Minor

    DS-8201a Versus T-DM1 for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive, Unresectable and/or Metastatic Breast Cancer Previously Treated With Trastuzumab and Taxane [DESTINY-Breast03]

    Trial completed

    Also in this update: Study completion date changed from estimate of Jul 30, 2026 to Aug 31, 2026

    Daiichi SankyoPhase 3 NCT03529110 Registry history of NCT03529110 on ClinicalTrials.gov (opens the registry)

  2. Minor

    Ribociclib Administered Concurrently With Postoperative Radiation Therapy · High-Risk, HR+/HER2- Breast Cancer

    Enrollment closed, study ongoing

    Also in this update: Primary completion pushed from Oct 2026 to Feb 2027; Study completion moved earlier from Oct 2030 to Feb 2030

    University of Michigan Rogel Cancer CenterPhase 1 NCT05996107 Registry history of NCT05996107 on ClinicalTrials.gov (opens the registry)

  3. Minor

    Alternative Site Goserelin Acetate Injection for Ovarian Function Suppression (OFS) in Local and Locally Advanced Premenopausal Hormone Receptor Positive Breast Cancer Patients

    Primary completion pushed from Sep 26, 2028 to Dec 21, 2028

    Also in this update: Study completion moved earlier from Sep 26, 2029 to Jun 21, 2029

    Mayo ClinicPhase 2 NCT07460752 Registry history of NCT07460752 on ClinicalTrials.gov (opens the registry)

  4. Minor

    AVATARII · Stereotactic Ablative Body Radiotherapy (SABR) With Maintenance of Systemic Therapy Versus Physicians' Choice of Systemic Therapy for Oligoprogressive ER-positive, Her-2 Negative Breast Cancer II

    Primary and study completion pushed from Jun 2032 to Nov 1, 2032

    Peter MacCallum Cancer Centre, AustraliaNot applicable NCT06882499 Registry history of NCT06882499 on ClinicalTrials.gov (opens the registry)

  5. Minor

    SYNERGY · Paclitaxel + Carboplatin + Durvalumab With or Without Oleclumab for Previously Untreated Locally Recurrent Inoperable or Metastatic TNBC

    Study completion pushed from Dec 2025 to Dec 2028

    Also in this update: Primary completion date changed from estimate of Mar 2025 to May 21, 2021

    Jules Bordet InstitutePhase 1/2 NCT03616886 Registry history of NCT03616886 on ClinicalTrials.gov (opens the registry)

  6. Minor
    38 trials marked Unknown by the registry's verification sweep
    1. Minor

      PEMCLOCK · Association of Pembrolizumab Infusion Time and Efficacy · Non-metastatic Triple-negative Breast Cancer (TNBC) Treated With Neoadjuvant Chemotherapy and Immunotherapy

      Registry marked status Unknown (sponsor has not verified the record since Apr 2024); last known: Not Yet Recruiting

      Assistance Publique - Hôpitaux de ParisNot specified NCT06418139 Registry history of NCT06418139 on ClinicalTrials.gov (opens the registry)

      Changed

    2. Minor

      NASBP-B-09 · Anastrozole Adjuvant Trial - Study of Anastrozole Compared to NOLVADEX (Tamoxifen Citrate) for Adjuvant Treatment of Early Breast Cancer Clinical Studies), Adjunct Cytotoxic Chemotherapy and Malignant Joint Tumor

      Registry marked status Unknown (sponsor has not verified the record since Nov 2023); last known: Not Yet Recruiting

      DR. DIANE CHISESI NFS. MD. PHD.Not specified NCT06154590 Registry history of NCT06154590 on ClinicalTrials.gov (opens the registry)

      Changed

    Registry verification sweep

    Changed

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-10-16 NCT07878598 Efficacy of Complete Decongestive Therapy for Limb Lymphedema: Response Profile and… Ryazan State Medical University new
2026-10-16 NCT07877740 Feasibility of a Standardized Fascial Plane Block Protocol for Breast Cancer Surgery Hôpital Fribourgeois new
2026-10-16 NCT07877376 Impact of Cognitive Impairment on Chronic Pain in Breast Cancer Nadine ATTAL new
2026-10-15 NCT07874880 MTX-531-001 Phase 1 Study in Advanced Solid Tumors MEKanistic Therapeutics, Inc. new Phase 1
2026-10-08 NCT07864909 Physical Activity Education and Quality of Life Study in Breast Cancer Chemotherapy… International Hellenic University new
2026-10-08 NCT07865884 Tissue Validation of Mammographic Breast Arterial Calcification in Mastectomy Specimens Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital new
2026-10-08 NCT07865507 Divergent Long-Term Clinical Courses in Two Men With Breast Cancer Azerbaijan Medical University new
2026-10-06 NCT07861932 A Phase 1/2a Study of K-1728 in Advanced Solid Tumors KymaThera, Inc. new Phase 1/2
2026-10-02 NCT07856225 Clinical and Therapeutic Outcomes by Molecular Subtype in Breast Cancer Fundación Santa Fe de Bogota new
2026-09-30 NCT07850869 A Real-World Observational Study of Intratumoral H101 Oncolytic Adenovirus Combined With… Jie Yuan,MD new

Active trials by phase

Early Phase 1
43
Phase 1
337
Phase 1/2
269
Phase 2
940
Phase 2/3
34
Phase 3
398
Phase 4
68
Not charted: 2,306 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 4,395

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07436663 Comparative Study Between (SGLT-2i) and (DPP-4i) in the Prevention of DIC Tanta University Recruiting 2026-10-15
NCT07195344 Study Aiming to Compare the Plasma Exposure of the Payload (Free-DXd) in Patients Treated… Institut Claudius Regaud Recruiting 2026-10-08
NCT06274515 A Study to Investigate Mechanisms of Resistance to Breast Cancer Therapies Hoffmann-La Roche Recruiting 2026-10-06
NCT07257484 Tirzepatide's Role in Postmenopausal HR+ Breast Cancer Survivors Weill Medical College of Cornell University Recruiting 2026-07-22
NCT07252726 Evaluating Dose Timing (Morning vs Evening) of Endocrine-based Therapies in Metastatic… Ottawa Hospital Research Institute Recruiting 2026-07-17
NCT07600164 Real-world Study of Pyrotinib-containing Regimens of Advanced HER2-positive Breast Cancer Peking University People's Hospital Recruiting 2026-07-13
NCT07220967 A Study of Antibiotic Delivery to Prevent Infection After Breast Tissue Expander Placement Memorial Sloan Kettering Cancer Center Recruiting 2026-07-10
NCT07695259 Olaparib+Trastuzumab+Pertuzumab Neoadjuvant for Elderly HER2+ Breast Cancer Wen-Ming Cao Recruiting 2026-07-10
NCT05753618 Evaluating Omission of Granulocyte Colony-stimulating Factors in Breast Cancer Patients… Ottawa Hospital Research Institute Recruiting 2026-07-08
NCT06169371 Abemaciclib Dose Escalation to Maintain Intensity (ADE-MI) University of Illinois at Chicago Recruiting 2026-07-07
NCT05183126 Pharmacokinetic Study of Skeletal Muscle Area-based Paclitaxel Infusion in Patients With… University of Michigan Rogel Cancer Center Recruiting 2026-07-02
NCT05376878 An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+… City of Hope Medical Center Recruiting 2026-07-01
NCT03096418 Neoadjuvant Weekly Paclitaxel and Biomarkers of Therapy Response University of Wisconsin, Madison Recruiting 2026-06-16
NCT04921137 Evaluating Harms and Benefits of Endocrine Therapy in Patients ≥70 Years of Age With… Ottawa Hospital Research Institute Recruiting 2026-05-28
NCT07578064 A Randomized, Self-controlled Post-marketing Clinical Study on the Comparison of Shengbai… Hongxia Wang Recruiting 2026-05-11
NCT07042581 A Study of Revaree Plus in People With Breast Cancer Memorial Sloan Kettering Cancer Center Recruiting 2026-02-06
NCT04373564 Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based… Guerbet Recruiting 2026-01-22
NCT07308717 Gabapentin And Breast Surgery Decision Architecture Randomization Trial (GABS-DART)… Memorial Sloan Kettering Cancer Center Recruiting 2025-12-30
NCT07257679 Gentle Touch for Post-Mastectomy Lymphedema I.R.C.C.S. Fondazione Santa Lucia Recruiting 2025-12-02
NCT06934239 A Trial Comparing Screening Mammography With and Without Assistance From Artificial… Jonsson Comprehensive Cancer Center Recruiting 2025-11-26
NCT06230055 Intrathecal Chemotherapy Through Ommaya Reservoir Upon Her-2 Negative Breast Cancer With… Fudan University Recruiting 2025-11-25
NCT06072807 Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer Weill Medical College of Cornell University Recruiting 2025-11-24
NCT07158164 DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment Rutgers, The State University of New Jersey Recruiting 2025-11-13
NCT06574022 Post-mastectomy Recovery: Comparing Preoperative PECS-II Blocks With Intraoperative… University of Cincinnati Recruiting 2025-11-04
NCT06491680 Cardiotoxicity in Breast Cancer Patients Helwan University Recruiting 2025-09-22

Top sponsors by active trials in this area

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